| Date: | August 27, 2006 |
| Location: | Lexington, Kentucky |
| Aircraft: | Canadair CRJ-200ER |
| Reg: | N431CA |
| Airline: | Comair |
| Flight No: | 5191 |
| Fatalities: | 50 : 49 |
| The crew took off from the wrong and too short a runway, ran through the airport perimeter fence and impacted trees on an adjacent horse farm and burst into flames. The copilot was the only survivor. |